DNA-directed RNA polymerases I, II, and III subunit…

About DNA-directed RNA polymerases I, II, and III subunit RPABC5

DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) is a protein from Homo sapiens identified by UniProt accession P62875, 67 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	DNA-directed RNA polymerases I, II, and III subunit RPABC5
UniProt accession	P62875
Gene	POLR2L
Organism	Homo sapiens
Length	67 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
influenza · score 0.37
acrocephalosyndactyly · score 0.37
neurodegenerative disease · score 0.34
head and neck squamous cell carcinoma · score 0.26
cutaneous melanoma · score 0.24
body mass index · score 0.21
pulse pressure measurement · score 0.16
mean platelet volume · score 0.13
body weight · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62875-F1	alphafold	PREDICTED	92.93	—

Amino-acid sequence (67 residues)

MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL AHVDLIEKLL NYAPLEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L)