About Large ribosomal subunit protein uL2
Large ribosomal subunit protein uL2 (RPL8) is a protein
from Homo sapiens identified by UniProt accession
P62917, 257 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Large ribosomal subunit protein uL2 |
|---|
| UniProt accession | P62917 |
|---|
| Gene | RPL8 |
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| Organism | Homo sapiens |
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| Length | 257 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- Duchenne muscular dystrophy · score 0.50
- cystic fibrosis · score 0.50
- influenza · score 0.46
- Diamond-Blackfan anemia · score 0.38
- Becker muscular dystrophy · score 0.29
- qualitative or quantitative defects of dystrophin · score 0.26
- aniridia · score 0.09
- diffuse large B-cell lymphoma · score 0.08
- hemophilia B · score 0.07
- non-Hodgkins lymphoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62917-F1 | alphafold | PREDICTED | 95.30 | — |
Amino-acid sequence (257 residues)
MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS ANRAVVGVVA GGGRIDKPIL KAGRAYHKYK AKRNCWPRVR GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA RRTGRLRGTK TVQEKEN
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