Peptidyl-prolyl cis-trans isomerase A (PPIA)

About Peptidyl-prolyl cis-trans isomerase A

Peptidyl-prolyl cis-trans isomerase A (PPIA) is a protein from Homo sapiens identified by UniProt accession P62937, 165 residues long. MolForge cross-references it against 0 known binders and 617 disease associations.

Target properties

Protein name	Peptidyl-prolyl cis-trans isomerase A
UniProt accession	P62937
Gene	PPIA
Organism	Homo sapiens
Length	165 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (617)

Diseases linked to this target (Open Targets).

HIV infection · score 0.62
dry eye syndrome · score 0.60
psoriasis · score 0.57
hepatitis C virus infection · score 0.56
atopic eczema · score 0.56
graft versus host disease · score 0.56
chronic kidney disease · score 0.56
Aplastic anemia · score 0.55
acute graft vs. host disease · score 0.52
inflammation · score 0.50

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62937-F1	alphafold	PREDICTED	98.06	—

Amino-acid sequence (165 residues)

MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards