Growth factor receptor-bound protein 2 (GRB2)

About Growth factor receptor-bound protein 2

Growth factor receptor-bound protein 2 (GRB2) is a protein from Homo sapiens identified by UniProt accession P62993, 217 residues long. MolForge cross-references it against 0 known binders and 249 disease associations.

Target properties

Protein name	Growth factor receptor-bound protein 2
UniProt accession	P62993
Gene	GRB2
Organism	Homo sapiens
Length	217 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (249)

Diseases linked to this target (Open Targets).

cancer · score 0.61
bone development disease · score 0.58
listeriosis · score 0.54
chronic myelogenous leukemia · score 0.53
body height · score 0.35
lung adenocarcinoma · score 0.30
endometrial cancer · score 0.30
breast adenocarcinoma · score 0.30
cutaneous melanoma · score 0.30
ovarian cancer · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P62993-F1	alphafold	PREDICTED	88.71	—

Amino-acid sequence (217 residues)

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards