About Transformer-2 protein homolog beta
Transformer-2 protein homolog beta (TRA2B) is a protein
from Homo sapiens identified by UniProt accession
P62995, 288 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Transformer-2 protein homolog beta |
|---|
| UniProt accession | P62995 |
|---|
| Gene | TRA2B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 288 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- Neurodevelopmental disorder · score 0.48
- Intellectual disability · score 0.37
- epilepsy · score 0.37
- age at menarche · score 0.36
- body height · score 0.33
- appendicular lean mass · score 0.30
- sitting height measurement · score 0.25
- microcephaly · score 0.18
- Microcephaly · score 0.18
- genetic disorder · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P62995-F1 | alphafold | PREDICTED | 57.62 | — |
Amino-acid sequence (288 residues)
MSDSGEQNYG ERESRSASRS GSAHGSGKSA RHTPARSRSK EDSRRSRSKS RSRSESRSRS RRSSRRHYTR SRSRSRSHRR SRSRSYSRDY RRRHSHSHSP MSTRRRHVGN RANPDPNCCL GVFGLSLYTT ERDLREVFSK YGPIADVSIV YDQQSRRSRG FAFVYFENVD DAKEAKERAN GMELDGRRIR VDFSITKRPH TPTPGIYMGR PTYGSSRRRD YYDRGYDRGY DDRDYYSRSY RGGGGGGGGW RAAQDRDQIY RRRSPSPYYS RGGYRSRSRS RSYSPRRY
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