Vesicle-associated membrane protein 2 (VAMP2)

About Vesicle-associated membrane protein 2

Vesicle-associated membrane protein 2 (VAMP2) is a protein from Homo sapiens identified by UniProt accession P63027, 116 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.

Target properties

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Disease associations (143)

Diseases linked to this target (Open Targets).

• neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements · score 0.65
• Intellectual disability · score 0.63
• botulism · score 0.53
• Global developmental delay · score 0.50
• Abnormality of movement · score 0.50
• Generalized hypotonia · score 0.50
• Seizure · score 0.50
• Cerebral visual impairment · score 0.50
• Autistic behavior · score 0.50
• Torticollis · score 0.47

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Amino-acid sequence (116 residues)

External references