Calcineurin subunit B type 1 (PPP3R1)

About Calcineurin subunit B type 1

Calcineurin subunit B type 1 (PPP3R1) is a protein from Homo sapiens identified by UniProt accession P63098, 170 residues long. MolForge cross-references it against 0 known binders and 264 disease associations.

Target properties

Protein name	Calcineurin subunit B type 1
UniProt accession	P63098
Gene	PPP3R1
Organism	Homo sapiens
Length	170 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (264)

Diseases linked to this target (Open Targets).

Varicose veins · score 0.32
Parkinson disease · score 0.31
Alzheimer disease · score 0.31
multiple sclerosis · score 0.31
lysosomal storage disease · score 0.31
neurodegenerative disease · score 0.31
body height · score 0.30
lean body mass · score 0.29
vein disorder · score 0.27
lymphatic system disease · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P63098-F1	alphafold	PREDICTED	91.14	—

Amino-acid sequence (170 residues)

MGNEASYPLE MCSHFDADEI KRLGKRFKKL DLDNSGSLSV EEFMSLPELQ QNPLVQRVID IFDTDGNGEV DFKEFIEGVS QFSVKGDKEQ KLRFAFRIYD MDKDGYISNG ELFQVLKMMV GNNLKDTQLQ QIVDKTIINA DKDGDGRISF EEFCAVVGGL DIHKKMVVDV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards