About 14-3-3 protein zeta/delta
14-3-3 protein zeta/delta (YWHAZ) is a protein
from Homo sapiens identified by UniProt accession
P63104, 245 residues long.
MolForge cross-references it against 0 known binders and
212 disease associations.
Target properties
| Protein name | 14-3-3 protein zeta/delta |
|---|
| UniProt accession | P63104 |
|---|
| Gene | YWHAZ |
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| Organism | Homo sapiens |
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| Length | 245 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (212)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- reticulocyte count · score 0.44
- body mass index · score 0.43
- reticulocyte measurement · score 0.41
- mean platelet volume · score 0.41
- chronotype measurement · score 0.39
- COVID-19 · score 0.37
- autosomal dominant non-syndromic intellectual disability · score 0.37
- severe acute respiratory syndrome · score 0.37
- Immature Reticulocyte Fraction Measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P63104-F1 | alphafold | PREDICTED | 93.91 | — |
Amino-acid sequence (245 residues)
MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QAESKVFYLK MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG EGGEN
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