About Ubiquitin-conjugating enzyme E2 B
Ubiquitin-conjugating enzyme E2 B (UBE2B) is a protein
from Homo sapiens identified by UniProt accession
P63146, 152 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Ubiquitin-conjugating enzyme E2 B |
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| UniProt accession | P63146 |
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| Gene | UBE2B |
|---|
| Organism | Homo sapiens |
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| Length | 152 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (186)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- partial chromosome Y deletion · score 0.09
- spermatogenic failure 65 · score 0.09
- spermatogenic failure, X-linked, 3 · score 0.09
- spermatogenic failure 56 · score 0.09
- spermatogenic failure 72 · score 0.09
- spermatogenic failure 40 · score 0.09
- spermatogenic failure 46 · score 0.09
- spermatogenic failure 18 · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P63146-F1 | alphafold | PREDICTED | 95.71 | — |
Amino-acid sequence (152 residues)
MSTPARRRLM RDFKRLQEDP PVGVSGAPSE NNIMQWNAVI FGPEGTPFED GTFKLVIEFS EEYPNKPPTV RFLSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS PANSQAAQLY QENKREYEKR VSAIVEQSWN DS
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