About Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) is a protein
from Homo sapiens identified by UniProt accession
P63151, 447 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform |
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| UniProt accession | P63151 |
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| Gene | PPP2R2A |
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| Organism | Homo sapiens |
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| Length | 447 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.57
- lysosomal storage disease · score 0.32
- neuroinflammatory disorder · score 0.32
- type 2 diabetes mellitus · score 0.29
- diastolic blood pressure · score 0.28
- endometrial cancer · score 0.27
- prostate carcinoma · score 0.26
- systolic blood pressure · score 0.26
- ovarian cancer · score 0.23
- breast adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P63151-F1 | alphafold | PREDICTED | 92.28 | — |
Amino-acid sequence (447 residues)
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN
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