About S-phase kinase-associated protein 1
S-phase kinase-associated protein 1 (SKP1) is a protein
from Homo sapiens identified by UniProt accession
P63208, 163 residues long.
MolForge cross-references it against 0 known binders and
97 disease associations.
Target properties
| Protein name | S-phase kinase-associated protein 1 |
|---|
| UniProt accession | P63208 |
|---|
| Gene | SKP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 163 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (97)
Diseases linked to this target (Open Targets).
- cancer · score 0.52
- HIV infection · score 0.50
- neurodegenerative disease · score 0.43
- head and neck squamous cell carcinoma · score 0.28
- neuroinflammatory disorder · score 0.26
- urinary bladder cancer · score 0.12
- keratoconus 1 · score 0.11
- mean platelet volume · score 0.10
- cervical squamous intraepithelial neoplasia · score 0.08
- urinary bladder carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P63208-F1 | alphafold | PREDICTED | 90.15 | — |
Amino-acid sequence (163 residues)
MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVRKENQWC EEK
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