About Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 (GNG3) is a protein
from Homo sapiens identified by UniProt accession
P63215, 75 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 |
|---|
| UniProt accession | P63215 |
|---|
| Gene | GNG3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 75 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- genetic disorder · score 0.27
- lung adenocarcinoma · score 0.23
- urinary bladder cancer · score 0.20
- glioblastoma multiforme · score 0.05
- generalised epilepsy · score 0.04
- Generalized epilepsy with febrile seizures-plus · score 0.04
- autosomal dominant epilepsy with auditory features · score 0.04
- developmental and epileptic encephalopathy, 9 · score 0.04
- generalized epilepsy with febrile seizures plus, type 2 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P63215-F1 | alphafold | PREDICTED | 85.64 | — |
Amino-acid sequence (75 residues)
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC EDPLITPVPT SENPFREKKF FCALL
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