Guanine nucleotide-binding protein G(I)/G(S)/G(O)…

About Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GNG5) is a protein from Homo sapiens identified by UniProt accession P63218, 68 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
UniProt accession	P63218
Gene	GNG5
Organism	Homo sapiens
Length	68 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.28
thyroid gland adenocarcinoma · score 0.27
breast cancer · score 0.07
bladder transitional cell carcinoma · score 0.07
hepatocellular carcinoma · score 0.07
neoplasm · score 0.07
breast carcinoma · score 0.03
cancer · score 0.02
Sepsis · score 0.02
Central Nervous System Neoplasm · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P63218-F1	alphafold	PREDICTED	88.68	—

Amino-acid sequence (68 residues)

MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR PQKVCSFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GNG5)