Actin, gamma-enteric smooth muscle (ACTG2)

About Actin, gamma-enteric smooth muscle

Actin, gamma-enteric smooth muscle (ACTG2) is a protein from Homo sapiens identified by UniProt accession P63267, 376 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	Actin, gamma-enteric smooth muscle
UniProt accession	P63267
Gene	ACTG2
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

visceral myopathy 1 · score 0.81
megacystis-microcolon-intestinal hypoperistalsis syndrome 5 · score 0.76
familial visceral myopathy · score 0.70
megacystis-microcolon-intestinal hypoperistalsis syndrome 5 · score 0.69
chronic intestinal pseudoobstruction · score 0.53
megacystis-microcolon-intestinal hypoperistalsis syndrome 1 · score 0.51
genetic disorder · score 0.49
megacystis-microcolon-intestinal hypoperistalsis syndrome · score 0.44
Fetal megacystis · score 0.37
myopathic intestinal pseudoobstruction · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P63267-F1	alphafold	PREDICTED	95.37	—

Amino-acid sequence (376 residues)

MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE EHPTLLTEAP LNPKANREKM TQIMFETFNV PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THNVPIYEGY ALPHAIMRLD LAGRDLTDYL MKILTERGYS FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS YELPDGQVIT IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK PEYDEAGPSI VHRKCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards