SUMO-conjugating enzyme UBC9 (UBE2I)

About SUMO-conjugating enzyme UBC9

SUMO-conjugating enzyme UBC9 (UBE2I) is a protein from Homo sapiens identified by UniProt accession P63279, 158 residues long. MolForge cross-references it against 0 known binders and 219 disease associations.

Target properties

Protein name	SUMO-conjugating enzyme UBC9
UniProt accession	P63279
Gene	UBE2I
Organism	Homo sapiens
Length	158 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (219)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
severe acute respiratory syndrome · score 0.46
COVID-19 · score 0.37
head and neck squamous cell carcinoma · score 0.27
lung adenocarcinoma · score 0.26
systolic blood pressure · score 0.25
gastric adenocarcinoma · score 0.24
neutrophil count · score 0.24
leukocyte count · score 0.23
urinary bladder cancer · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P63279-F1	alphafold	PREDICTED	97.33	—

Amino-acid sequence (158 residues)

MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG TPWEGGLFKL RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED KDWRPAITIK QILLGIQELL NEPNIQDPAQ AEAYTIYCQN RVEYEKRVRA QAKKFAPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards