About Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) is a protein
from Homo sapiens identified by UniProt accession
P67775, 309 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
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| UniProt accession | P67775 |
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| Gene | PPP2CA |
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| Organism | Homo sapiens |
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| Length | 309 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (186)
Diseases linked to this target (Open Targets).
- Houge-Janssens syndrome 3 · score 0.77
- neurodegenerative disease · score 0.54
- cancer · score 0.54
- Seizure · score 0.46
- Intellectual disability · score 0.46
- Global developmental delay · score 0.46
- Feeding difficulties · score 0.46
- Hypotonia · score 0.46
- language impairment · score 0.46
- chronic myelogenous leukemia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P67775-F1 | alphafold | PREDICTED | 95.07 | — |
Amino-acid sequence (309 residues)
MDEKVFTKEL DQWIEQLNEC KQLSESQVKS LCEKAKEILT KESNVQEVRC PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYRER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV TRRTPDYFL
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