About Signal peptidase complex catalytic subunit SEC11A
Signal peptidase complex catalytic subunit SEC11A (SEC11A) is a protein
from Homo sapiens identified by UniProt accession
P67812, 179 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Signal peptidase complex catalytic subunit SEC11A |
|---|
| UniProt accession | P67812 |
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| Gene | SEC11A |
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| Organism | Homo sapiens |
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| Length | 179 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- electrocardiography · score 0.27
- mean corpuscular volume · score 0.19
- transmembrane glycoprotein NMB measurement · score 0.19
- glomerular filtration rate · score 0.18
- PR interval · score 0.14
- hypertrophic cardiomyopathy · score 0.14
- aspartate aminotransferase measurement · score 0.13
- platelet count · score 0.12
- creatinine measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P67812-F1 | alphafold | PREDICTED | 90.76 | — |
Amino-acid sequence (179 residues)
MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM VITGSESPIV VVLSGSMEPA FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK IHEKQNGHIK FLTKGDNNAV DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG IVTILMNDYP KFKYAVLFLL GLFVLVHRE
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