About Tropomyosin alpha-4 chain
Tropomyosin alpha-4 chain (TPM4) is a protein
from Homo sapiens identified by UniProt accession
P67936, 248 residues long.
MolForge cross-references it against 0 known binders and
170 disease associations.
Target properties
| Protein name | Tropomyosin alpha-4 chain |
|---|
| UniProt accession | P67936 |
|---|
| Gene | TPM4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 248 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (170)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.63
- cancer · score 0.48
- platelet count · score 0.47
- inflammatory myofibroblastic tumor · score 0.37
- autosomal dominant macrothrombocytopenia · score 0.37
- Lung Inflammatory Myofibroblastic Tumor · score 0.37
- platelet component distribution width · score 0.34
- lung adenocarcinoma · score 0.23
- liver fibrosis measurement · score 0.23
- breast adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P67936-F1 | alphafold | PREDICTED | 93.10 | — |
Amino-acid sequence (248 residues)
MAGLNSLEAV KRKIQALQQQ ADEAEDRAQG LQRELDGERE RREKAEGDVA ALNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRAMK DEEKMEIQEM QLKEAKHIAE EADRKYEEVA RKLVILEGEL ERAEERAEVS ELKCGDLEEE LKNVTNNLKS LEAASEKYSE KEDKYEEEIK LLSDKLKEAE TRAEFAERTV AKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ TLNELNCI
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