Actin, alpha cardiac muscle 1 (ACTC1)

About Actin, alpha cardiac muscle 1

Actin, alpha cardiac muscle 1 (ACTC1) is a protein from Homo sapiens identified by UniProt accession P68032, 377 residues long. MolForge cross-references it against 0 known binders and 138 disease associations.

Target properties

Protein name	Actin, alpha cardiac muscle 1
UniProt accession	P68032
Gene	ACTC1
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (138)

Diseases linked to this target (Open Targets).

hypertrophic cardiomyopathy · score 0.80
hypertrophic cardiomyopathy 11 · score 0.79
atrial septal defect 5 · score 0.73
left ventricular noncompaction · score 0.71
Rare familial disorder with hypertrophic cardiomyopathy · score 0.55
Abnormality of the cardiovascular system · score 0.47
cardiomyopathy · score 0.46
familial hypertrophic cardiomyopathy · score 0.44
dilated cardiomyopathy · score 0.42
familial isolated dilated cardiomyopathy · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P68032-F1	alphafold	PREDICTED	95.36	—

Amino-acid sequence (377 residues)

MCDDEETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS KQEYDEAGPS IVHRKCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards