About Ubiquitin-conjugating enzyme E2 L3
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) is a protein
from Homo sapiens identified by UniProt accession
P68036, 154 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | Ubiquitin-conjugating enzyme E2 L3 |
|---|
| UniProt accession | P68036 |
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| Gene | UBE2L3 |
|---|
| Organism | Homo sapiens |
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| Length | 154 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (124)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- high density lipoprotein cholesterol measurement · score 0.31
- total cholesterol measurement · score 0.28
- lymphocyte count · score 0.24
- neutrophil percentage of leukocytes · score 0.22
- Red cell distribution width · score 0.22
- rheumatoid arthritis · score 0.22
- systemic lupus erythematosus · score 0.22
- mean corpuscular volume · score 0.22
- pulse pressure measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P68036-F1 | alphafold | PREDICTED | 95.54 | — |
Amino-acid sequence (154 residues)
MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK RPVD
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