Elongation factor 1-alpha 1 (EEF1A1)

About Elongation factor 1-alpha 1

Elongation factor 1-alpha 1 (EEF1A1) is a protein from Homo sapiens identified by UniProt accession P68104, 462 residues long. MolForge cross-references it against 0 known binders and 217 disease associations.

Target properties

Protein name	Elongation factor 1-alpha 1
UniProt accession	P68104
Gene	EEF1A1
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (217)

Diseases linked to this target (Open Targets).

mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency · score 0.53
severe acute respiratory syndrome · score 0.37
Red cell distribution width · score 0.35
Abnormal brain morphology · score 0.33
genetic disorder · score 0.18
breast adenocarcinoma · score 0.18
low grade glioma · score 0.17
endometrial cancer · score 0.17
mean corpuscular hemoglobin concentration · score 0.15
glioblastoma multiforme · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P68104-F1	alphafold	PREDICTED	88.14	—

Amino-acid sequence (462 residues)

MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK IGYNPDTVAF VPISGWNGDN MLEPSANMPW FKGWKVTRKD GNASGTTLLE ALDCILPPTR PTDKPLRLPL QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP GQISAGYAPV LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA IVDMVPGKPM CVESFSDYPP LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK VTKSAQKAQK AK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards