Actin, alpha skeletal muscle (ACTA1)

About Actin, alpha skeletal muscle

Actin, alpha skeletal muscle (ACTA1) is a protein from Homo sapiens identified by UniProt accession P68133, 377 residues long. MolForge cross-references it against 0 known binders and 880 disease associations.

Target properties

Protein name	Actin, alpha skeletal muscle
UniProt accession	P68133
Gene	ACTA1
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (880)

Diseases linked to this target (Open Targets).

nemaline myopathy 3 · score 0.86
severe congenital nemaline myopathy · score 0.67
progressive scapulohumeroperoneal distal myopathy · score 0.65
congenital myopathy 2b, severe infantile, autosomal recessive · score 0.62
congenital fiber-type disproportion myopathy · score 0.60
alpha-actinopathy · score 0.54
nemaline myopathy · score 0.49
neuromuscular disease · score 0.46
dilated cardiomyopathy · score 0.45
myopathy · score 0.44

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P68133-F1	alphafold	PREDICTED	95.10	—

Amino-acid sequence (377 residues)

MCDEDETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV MSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIT KQEYDEAGPS IVHRKCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards