Tubulin alpha-4A chain (TUBA4A)

About Tubulin alpha-4A chain

Tubulin alpha-4A chain (TUBA4A) is a protein from Homo sapiens identified by UniProt accession P68366, 448 residues long. MolForge cross-references it against 0 known binders and 251 disease associations.

Target properties

Protein name	Tubulin alpha-4A chain
UniProt accession	P68366
Gene	TUBA4A
Organism	Homo sapiens
Length	448 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (251)

Diseases linked to this target (Open Targets).

amyotrophic lateral sclerosis · score 0.57
viral disease · score 0.46
lung cancer · score 0.37
breast cancer · score 0.37
non-small cell lung carcinoma · score 0.37
peritoneal neoplasm · score 0.37
malignant epithelial tumor of ovary · score 0.37
fallopian tube neoplasm · score 0.37
neoplasm · score 0.35
neutropenia · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P68366-F1	alphafold	PREDICTED	91.83	—

Amino-acid sequence (448 residues)

MRECISVHVG QAGVQMGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFT TFFCETGAGK HVPRAVFVDL EPTVIDEIRN GPYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDPVLD RIRKLSDQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIAAIKTKRS IQFVDWCPTG FKVGINYQPP TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE AREDMAALEK DYEEVGIDSY EDEDEGEE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards