Tubulin beta-4B chain (TUBB4B)

About Tubulin beta-4B chain

Tubulin beta-4B chain (TUBB4B) is a protein from Homo sapiens identified by UniProt accession P68371, 445 residues long. MolForge cross-references it against 0 known binders and 498 disease associations.

Target properties

Protein name	Tubulin beta-4B chain
UniProt accession	P68371
Gene	TUBB4B
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (498)

Diseases linked to this target (Open Targets).

Leber congenital amaurosis with early-onset deafness · score 0.63
non-small cell lung carcinoma · score 0.62
head and neck squamous cell carcinoma · score 0.61
breast cancer · score 0.61
neoplasm · score 0.60
breast carcinoma · score 0.60
ovarian cancer · score 0.60
breast neoplasm · score 0.60
gout · score 0.59
acute lymphoblastic leukemia · score 0.59

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P68371-F1	alphafold	PREDICTED	92.27	—

Amino-acid sequence (445 residues)

MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVV PSPKVSDTVV EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEEGEFEEEA EEEVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards