Histone H3.1 (H3C1)

About Histone H3.1

Histone H3.1 (H3C1) is a protein from Homo sapiens identified by UniProt accession P68431, 136 residues long. MolForge cross-references it against 0 known binders and 701 disease associations.

Target properties

Protein name	Histone H3.1
UniProt accession	P68431
Gene	H3C1
Organism	Homo sapiens
Length	136 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (701)

Diseases linked to this target (Open Targets).

viral disease · score 0.51
infectious disease · score 0.51
breast carcinoma · score 0.44
melanoma · score 0.44
diffuse large B-cell lymphoma · score 0.40
cancer · score 0.38
breast ductal adenocarcinoma · score 0.37
anaplastic astrocytoma · score 0.37
oligodendroglioma · score 0.37
lobular breast carcinoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P68431-F1	alphafold	PREDICTED	86.04	—

Amino-acid sequence (136 residues)

MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEACEAY LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards