Hemoglobin subunit beta (HBB)

About Hemoglobin subunit beta

Hemoglobin subunit beta (HBB) is a protein from Homo sapiens identified by UniProt accession P68871, 147 residues long. MolForge cross-references it against 0 known binders and 434 disease associations.

Target properties

Protein name	Hemoglobin subunit beta
UniProt accession	P68871
Gene	HBB
Organism	Homo sapiens
Length	147 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (434)

Diseases linked to this target (Open Targets).

beta-thalassemia HBB/LCRB · score 0.81
sickle cell anemia · score 0.79
Beta-thalassemia · score 0.78
dominant beta-thalassemia · score 0.76
hemoglobin M disease · score 0.74
Heinz body anemia · score 0.72
beta thalassemia · score 0.71
erythrocytosis, familial, 6 · score 0.71
mean corpuscular volume · score 0.69
mean corpuscular hemoglobin concentration · score 0.69

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P68871-F1	alphafold	PREDICTED	97.18	—

Amino-acid sequence (147 residues)

MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS TPDAVMGNPK VKAHGKKVLG AFSDGLAHLD NLKGTFATLS ELHCDKLHVD PENFRLLGNV LVCVLAHHFG KEFTPPVQAA YQKVVAGVAN ALAHKYH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards