About Hemoglobin subunit gamma-1
Hemoglobin subunit gamma-1 (HBG1) is a protein
from Homo sapiens identified by UniProt accession
P69891, 147 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Hemoglobin subunit gamma-1 |
|---|
| UniProt accession | P69891 |
|---|
| Gene | HBG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 147 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- Hereditary persistence of fetal hemoglobin - beta-thalassemia · score 0.51
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.46
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome · score 0.37
- delta-beta-thalassemia · score 0.37
- Red cell distribution width · score 0.18
- hemoglobin E disease · score 0.14
- blood protein measurement · score 0.10
- reticulocyte count · score 0.07
- PHF-tau measurement · score 0.06
- fetal hemoglobin measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P69891-F1 | alphafold | PREDICTED | 96.86 | — |
Amino-acid sequence (147 residues)
MGHFTEEDKA TITSLWGKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPK VKAHGKKVLT SLGDATKHLD DLKGTFAQLS ELHCDKLHVD PENFKLLGNV LVTVLAIHFG KEFTPEVQAS WQKMVTAVAS ALSSRYH
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