SH3 domain-binding protein 2 (SH3BP2)

About SH3 domain-binding protein 2

SH3 domain-binding protein 2 (SH3BP2) is a protein from Homo sapiens identified by UniProt accession P78314, 561 residues long. MolForge cross-references it against 0 known binders and 365 disease associations.

Target properties

Protein name	SH3 domain-binding protein 2
UniProt accession	P78314
Gene	SH3BP2
Organism	Homo sapiens
Length	561 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (365)

Diseases linked to this target (Open Targets).

cherubism · score 0.81
platelet count · score 0.26
chronotype measurement · score 0.23
genetic disorder · score 0.19
gastrointestinal stromal tumor · score 0.09
common variable immunodeficiency · score 0.08
isolated agammaglobulinemia · score 0.08
Gorham-Stout disease · score 0.08
BENTA disease · score 0.08
ICF syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78314-F1	alphafold	PREDICTED	65.30	—

Amino-acid sequence (561 residues)

MAAEEMHWPV PMKAIGAQNL LTMPGGVAKA GYLHKKGGTQ LQLLKWPLRF VIIHKRCVYY FKSSTSASPQ GAFSLSGYNR VMRAAEETTS NNVFPFKIIH ISKKHRTWFF SASSEEERKS WMALLRREIG HFHEKKDLPL DTSDSSSDTD SFYGAVERPV DISLSPYPTD NEDYEHDDED DSYLEPDSPE PGRLEDALMH PPAYPPPPVP TPRKPAFSDM PRAHSFTSKG PGPLLPPPPP KHGLPDVGLA AEDSKRDPLC PRRAEPCPRV PATPRRMSDP PLSTMPTAPG LRKPPCFRES ASPSPEPWTP GHGACSTSSA AIMATATSRN CDKLKSFHLS PRGPPTSEPP PVPANKPKFL KIAEEDPPRE AAMPGLFVPP VAPRPPALKL PVPEAMARPA VLPRPEKPQL PHLQRSPPDG QSFRSFSFEK PRQPSQADTG GDDSDEDYEK VPLPNSVFVN TTESCEVERL FKATSPRGEP QDGLYCIRNS STKSGKVLVV WDETSNKVRN YRIFEKDSKF YLEGEVLFVS VGSMVEHYHT HVLPSHQSLL LRHPYGYTGP R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards