About E3 ubiquitin-protein ligase RNF4
E3 ubiquitin-protein ligase RNF4 (RNF4) is a protein
from Homo sapiens identified by UniProt accession
P78317, 190 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF4 |
|---|
| UniProt accession | P78317 |
|---|
| Gene | RNF4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 190 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (89)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- clear cell renal carcinoma · score 0.21
- eosinophil count · score 0.16
- systolic blood pressure · score 0.10
- intelligence · score 0.09
- neoplasm · score 0.09
- health study participation · score 0.07
- cancer · score 0.05
- eosinophil percentage of leukocytes · score 0.05
- 46,XY complete gonadal dysgenesis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78317-F1 | alphafold | PREDICTED | 72.95 | — |
Amino-acid sequence (190 residues)
MSTRKRRGGA INSRQAQKRT REATSTPEIS LEAEPIELVE TAGDEIVDLT CESLEPVVVD LTHNDSVVIV DERRRPRRNA RRLPQDHADS CVVSSDDEEL SRDRDVYVTT HTPRNARDEG ATGLRPSGTV SCPICMDGYS EIVQNGRLIV STECGHVFCS QCLRDSLKNA NTCPTCRKKI NHKRYHPIYI
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