Immunoglobulin-binding protein 1 (IGBP1)

About Immunoglobulin-binding protein 1

Immunoglobulin-binding protein 1 (IGBP1) is a protein from Homo sapiens identified by UniProt accession P78318, 339 residues long. MolForge cross-references it against 0 known binders and 384 disease associations.

Target properties

Protein name	Immunoglobulin-binding protein 1
UniProt accession	P78318
Gene	IGBP1
Organism	Homo sapiens
Length	339 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (384)

Diseases linked to this target (Open Targets).

corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome · score 0.54
Agenesis of the corpus callosum - intellectual disability - coloboma - micrognathia · score 0.43
neurodegenerative disease · score 0.26
breast cancer · score 0.07
hepatocellular carcinoma · score 0.05
esophageal squamous cell carcinoma · score 0.05
Systemic lupus erythematosus · score 0.05
neoplasm · score 0.04
cancer · score 0.03
allergic asthma · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78318-F1	alphafold	PREDICTED	81.73	—

Amino-acid sequence (339 residues)

MAAEDELQLP RLPELFETGR QLLDEVEVAT EPAGSRIVQE KVFKGLDLLE KAAEMLSQLD LFSRNEDLEE IASTDLKYLL VPAFQGALTM KQVNPSKRLD HLQRAREHFI NYLTQCHCYH VAEFELPKTM NNSAENHTAN SSMAYPSLVA MASQRQAKIQ RYKQKKELEH RLSAMKSAVE SGQADDERVR EYYLLHLQRW IDISLEEIES IDQEIKILRE RDSSREASTS NSSRQERPPV KPFILTRNMA QAKVFGAGYP SLPTMTVSDW YEQHRKYGAL PDQGIAKAAP EEFRKAAQQQ EEQEEKEEED DEQTLHRARE WDDWKDTHPR GYGNRQNMG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards