About Tyrosine-protein phosphatase non-receptor type substrate 1
Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) is a protein
from Homo sapiens identified by UniProt accession
P78324, 504 residues long.
MolForge cross-references it against 0 known binders and
439 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type substrate 1 |
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| UniProt accession | P78324 |
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| Gene | SIRPA |
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| Organism | Homo sapiens |
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| Length | 504 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (439)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.51
- platelet count · score 0.49
- blood protein measurement · score 0.47
- platelet component distribution width · score 0.47
- platelet crit · score 0.47
- Red cell distribution width · score 0.45
- reticulocyte measurement · score 0.43
- mean corpuscular volume · score 0.42
- reticulocyte count · score 0.42
- mean corpuscular hemoglobin concentration · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78324-F1 | alphafold | PREDICTED | 77.82 | — |
Amino-acid sequence (504 residues)
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET ATLRCTATSL IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK AQGSTSSTRL HEPEKNAREI TQDTNDITYA DLNLPKGKKP APQAAEPNNH TEYASIQTSP QPASEDTLTY ADLDMVHLNR TPKQPAPKPE PSFSEYASVQ VPRK
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