About Disintegrin and metalloproteinase domain-containing protein 8
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) is a protein
from Homo sapiens identified by UniProt accession
P78325, 824 residues long.
MolForge cross-references it against 0 known binders and
177 disease associations.
Target properties
| Protein name | Disintegrin and metalloproteinase domain-containing protein 8 |
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| UniProt accession | P78325 |
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| Gene | ADAM8 |
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| Organism | Homo sapiens |
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| Length | 824 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (177)
Diseases linked to this target (Open Targets).
- genetic disorder · score 0.12
- neoplasm · score 0.11
- triple-negative breast cancer · score 0.10
- glioblastoma multiforme · score 0.09
- hepatocellular carcinoma · score 0.09
- mucous membrane pemphigoid · score 0.09
- microphthalmia with limb anomalies · score 0.09
- gonorrhea · score 0.08
- Cerebral ischemia · score 0.08
- cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78325-F1 | alphafold | PREDICTED | 73.74 | — |
Amino-acid sequence (824 residues)
MRGLGLWLLG AMMLPAIAPS RPWALMEQYE VVLPWRLPGP RVRRALPSHL GLHPERVSYV LGATGHNFTL HLRKNRDLLG SGYTETYTAA NGSEVTEQPR GQDHCFYQGH VEGYPDSAAS LSTCAGLRGF FQVGSDLHLI EPLDEGGEGG RHAVYQAEHL LQTAGTCGVS DDSLGSLLGP RTAAVFRPRP GDSLPSRETR YVELYVVVDN AEFQMLGSEA AVRHRVLEVV NHVDKLYQKL NFRVVLVGLE IWNSQDRFHV SPDPSVTLEN LLTWQARQRT RRHLHDNVQL ITGVDFTGTT VGFARVSAMC SHSSGAVNQD HSKNPVGVAC TMAHEMGHNL GMDHDENVQG CRCQERFEAG RCIMAGSIGS SFPRMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK ASRYRADMCG VLQCKGGQQP LGRAICIVDV CHALTTEDGT AYEPVPEGTR CGPEKVCWKG RCQDLHVYRS SNCSAQCHNH GVCNHKQECH CHAGWAPPHC AKLLTEVHAA SGSLPVFVVV VLVLLAVVLV TLAGIIVYRK ARSRILSRNV APKTTMGRSN PLFHQAASRV PAKGGAPAPS RGPQELVPTT HPGQPARHPA SSVALKRPPP APPVTVSSPP FPVPVYTRQA PKQVIKPTFA PPVPPVKPGA GAANPGPAEG AVGPKVALKP PIQRKQGAGA PTAP
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