About Phosphoserine phosphatase
Phosphoserine phosphatase (PSPH) is a protein
from Homo sapiens identified by UniProt accession
P78330, 225 residues long.
MolForge cross-references it against 0 known binders and
230 disease associations.
Target properties
| Protein name | Phosphoserine phosphatase |
|---|
| UniProt accession | P78330 |
|---|
| Gene | PSPH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 225 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (230)
Diseases linked to this target (Open Targets).
- PSPH deficiency · score 0.73
- 3-phosphoserine phosphatase deficiency · score 0.66
- neurodegenerative disease · score 0.54
- Neu-Laxova syndrome 1 · score 0.47
- glycine measurement · score 0.35
- serum alanine aminotransferase measurement · score 0.33
- amino acid measurement · score 0.32
- blood metabolite measurement · score 0.32
- Intellectual disability · score 0.27
- Seizure · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78330-F1 | alphafold | PREDICTED | 92.72 | — |
Amino-acid sequence (225 residues)
MVSHSELRKL FYSADAVCFD VDSTVIREEG IDELAKICGV EDAVSEMTRR AMGGAVPFKA ALTERLALIQ PSREQVQRLI AEQPPHLTPG IRELVSRLQE RNVQVFLISG GFRSIVEHVA SKLNIPATNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK VIKLLKEKFH FKKIIMIGDG ATDMEACPPA DAFIGFGGNV IRQQVKDNAK WYITDFVELL GELEE
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