About Pituitary homeobox 1
Pituitary homeobox 1 (PITX1) is a protein
from Homo sapiens identified by UniProt accession
P78337, 314 residues long.
MolForge cross-references it against 0 known binders and
700 disease associations.
Target properties
| Protein name | Pituitary homeobox 1 |
|---|
| UniProt accession | P78337 |
|---|
| Gene | PITX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 314 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (700)
Diseases linked to this target (Open Targets).
- clubfoot · score 0.76
- brachydactyly-elbow wrist dysplasia syndrome · score 0.68
- Brachydactyly - elbow wrist dysplasia · score 0.64
- Talipes equinovarus · score 0.48
- neurodegenerative disease · score 0.48
- lean body mass · score 0.46
- colorectal cancer · score 0.46
- body height · score 0.45
- heel bone mineral density · score 0.43
- appendicular lean mass · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78337-F1 | alphafold | PREDICTED | 61.08 | — |
Amino-acid sequence (314 residues)
MDAFKGGMSL ERLPEGLRPP PPPPHDMGPA FHLARPADPR EPLENSASES SDTELPEKER GGEPKGPEDS GAGGTGCGGA DDPAKKKKQR RQRTHFTSQQ LQELEATFQR NRYPDMSMRE EIAVWTNLTE PRVRVWFKNR RAKWRKRERN QQLDLCKGGY VPQFSGLVQP YEDVYAAGYS YNNWAAKSLA PAPLSTKSFT FFNSMSPLSS QSMFSAPSSI SSMTMPSSMG PGAVPGMPNS GLNNINNLTG SSLNSAMSPG ACPYGTPASP YSVYRDTCNS SLASLRLKSK QHSSFGYGGL QGPASGLNAC QYNS
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