About Acid-sensing ion channel 1
Acid-sensing ion channel 1 (ASIC1) is a protein
from Homo sapiens identified by UniProt accession
P78348, 528 residues long.
MolForge cross-references it against 0 known binders and
137 disease associations.
Target properties
| Protein name | Acid-sensing ion channel 1 |
|---|
| UniProt accession | P78348 |
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| Gene | ASIC1 |
|---|
| Organism | Homo sapiens |
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| Length | 528 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (137)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.16
- Seizure · score 0.12
- head and neck squamous cell carcinoma · score 0.12
- neoplasm · score 0.08
- BMI-adjusted hip circumference · score 0.05
- hypertriglyceridemia 2 · score 0.05
- cholesterol-ester transfer protein deficiency · score 0.05
- Fish-eye disease · score 0.04
- glioblastoma multiforme · score 0.04
- Combined hyperlipidemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78348-F1 | alphafold | PREDICTED | 83.77 | — |
Amino-acid sequence (528 residues)
MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD FFDSYSITAC RIDCETRYLV ENCNCRMVHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDFTC
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