About Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B) is a protein
from Homo sapiens identified by UniProt accession
P78356, 416 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| UniProt accession | P78356 |
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| Gene | PIP4K2B |
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| Organism | Homo sapiens |
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| Length | 416 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (90)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- breast adenocarcinoma · score 0.29
- low grade glioma · score 0.29
- thyroid gland adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- lung adenocarcinoma · score 0.26
- heel bone mineral density · score 0.24
- lean body mass · score 0.23
- gastric adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78356-F1 | alphafold | PREDICTED | 84.14 | — |
Amino-acid sequence (416 residues)
MSSNCTSTTA VAVAPLSASK TKTKKKHFVC QKVKLFRASE PILSVLMWGV NHTINELSNV PVPVMLMPDD FKAYSKIKVD NHLFNKENLP SRFKFKEYCP MVFRNLRERF GIDDQDYQNS VTRSAPINSD SQGRCGTRFL TTYDRRFVIK TVSSEDVAEM HNILKKYHQF IVECHGNTLL PQFLGMYRLT VDGVETYMVV TRNVFSHRLT VHRKYDLKGS TVAREASDKE KAKDLPTFKD NDFLNEGQKL HVGEESKKNF LEKLKRDVEF LAQLKIMDYS LLVGIHDVDR AEQEEMEVEE RAEDEECEND GVGGNLLCSY GTPPDSPGNL LSFPRFFGPG EFDPSVDVYA MKSHESSPKK EVYFMAIIDI LTPYDTKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFNEF MSNILT
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