Homeobox protein Nkx-3.2 (NKX3-2)

About Homeobox protein Nkx-3.2

Homeobox protein Nkx-3.2 (NKX3-2) is a protein from Homo sapiens identified by UniProt accession P78367, 333 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.

Target properties

Protein name	Homeobox protein Nkx-3.2
UniProt accession	P78367
Gene	NKX3-2
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (127)

Diseases linked to this target (Open Targets).

spondylo-megaepiphyseal-metaphyseal dysplasia · score 0.74
connective tissue disease · score 0.32
body height · score 0.32
sitting height measurement · score 0.28
hip geometry · score 0.26
drug use measurement · score 0.19
genetic disorder · score 0.19
FEV/FVC ratio · score 0.10
BMI-adjusted waist circumference · score 0.10
vital capacity · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78367-F1	alphafold	PREDICTED	59.14	—

Amino-acid sequence (333 residues)

MAVRGANTLT SFSIQAILNK KEERGGLAAP EGRPAPGGTA ASVAAAPAVC CWRLFGERDA GALGGAEDSL LASPAGTRTA AGRTAESPEG WDSDSALSEE NESRRRCADA RGASGAGLAG GSLSLGQPVC ELAASKDLEE EAAGRSDSEM SASVSGDRSP RTEDDGVGPR GAHVSALCSG AGGGGGSGPA GVAEEEEEPA APKPRKKRSR AAFSHAQVFE LERRFNHQRY LSGPERADLA ASLKLTETQV KIWFQNRRYK TKRRQMAADL LASAPAAKKV AVKVLVRDDQ RQYLPGEVLR PPSLLPLQPS YYYPYYCLPG WALSTCAAAA GTQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards