Casein kinase I isoform gamma-2 (CSNK1G2)

About Casein kinase I isoform gamma-2

Casein kinase I isoform gamma-2 (CSNK1G2) is a protein from Homo sapiens identified by UniProt accession P78368, 415 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.

Target properties

Protein name	Casein kinase I isoform gamma-2
UniProt accession	P78368
Gene	CSNK1G2
Organism	Homo sapiens
Length	415 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (99)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.39
body mass index · score 0.32
neurodegenerative disease · score 0.19
C-reactive protein measurement · score 0.19
endometrial cancer · score 0.18
lung adenocarcinoma · score 0.10
lean body mass · score 0.09
primary ovarian insufficiency · score 0.06
46,XX gonadal dysgenesis · score 0.06
Isolated follicle stimulating hormone deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78368-F1	alphafold	PREDICTED	79.05	—

Amino-acid sequence (415 residues)

MDFDKKGGKG ETEEGRRMSK AGGGRSSHGI RSSGTSSGVL MVGPNFRVGK KIGCGNFGEL RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSATE GVPQVYYFGP CGKYNAMVLE LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI TRMEYVHTKS LIYRDVKPEN FLVGRPGTKR QHAIHIIDFG LAKEYIDPET KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH MFMYFLRGSL PWQGLKADTL KERYQKIGDT KRATPIEVLC ENFPEEMATY LRYVRRLDFF EKPDYDYLRK LFTDLFDRSG FVFDYEYDWA GKPLPTPIGT VHTDLPSQPQ LRDKTQPHSK NQALNSTNGE LNADDPTAGH SNAPITAPAE VEVADETKCC CFFKRRKRKS LQRHK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards