About T-complex protein 1 subunit beta
T-complex protein 1 subunit beta (CCT2) is a protein
from Homo sapiens identified by UniProt accession
P78371, 535 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | T-complex protein 1 subunit beta |
|---|
| UniProt accession | P78371 |
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| Gene | CCT2 |
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| Organism | Homo sapiens |
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| Length | 535 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (108)
Diseases linked to this target (Open Targets).
- Leber congenital amaurosis · score 0.38
- head and neck squamous cell carcinoma · score 0.26
- glioblastoma multiforme · score 0.25
- lung adenocarcinoma · score 0.25
- endometrial cancer · score 0.25
- gastric adenocarcinoma · score 0.25
- breast adenocarcinoma · score 0.25
- serum gamma-glutamyl transferase measurement · score 0.22
- diastolic blood pressure · score 0.20
- small cell lung carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78371-F1 | alphafold | PREDICTED | 89.80 | — |
Amino-acid sequence (535 residues)
MASLSLAPVN IFKAGADEER AETARLTSFI GAIAIGDLVK STLGPKGMDK ILLSSGRDAS LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT SVTVLAAELL REAESLIAKK IHPQTIIAGW REATKAAREA LLSSAVDHGS DEVKFRQDLM NIAGTTLSSK LLTHHKDHFT KLAVEAVLRL KGSGNLEAIH IIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA NTGMDTDKIK IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE EVMIGEDKLI HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT VKDSRTVYGG GCSEMLMAHA VTQLANRTPG KEAVAMESYA KALRMLPTII ADNAGYDSAD LVAQLRAAHS EGNTTAGLDM REGTIGDMAI LGITESFQVK RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC
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