Oxidized low-density lipoprotein receptor 1 (OLR1)

About Oxidized low-density lipoprotein receptor 1

Oxidized low-density lipoprotein receptor 1 (OLR1) is a protein from Homo sapiens identified by UniProt accession P78380, 273 residues long. MolForge cross-references it against 0 known binders and 341 disease associations.

Target properties

Protein name	Oxidized low-density lipoprotein receptor 1
UniProt accession	P78380
Gene	OLR1
Organism	Homo sapiens
Length	273 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (341)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.32
glioblastoma multiforme · score 0.20
myocardial infarction · score 0.20
breast adenocarcinoma · score 0.18
head and neck squamous cell carcinoma · score 0.14
lectin-like oxidized LDL receptor 1 measurement · score 0.12
coronary artery disease · score 0.11
neoplasm · score 0.10
non-small cell lung carcinoma · score 0.10
cancer · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78380-F1	alphafold	PREDICTED	87.45	—

Amino-acid sequence (273 residues)

MTFDDLKIQT VKDQPDEKSN GKKAKGLQFL YSPWWCLAAA TLGVLCLGLV VTIMVLGMQL SQVSDLLTQE QANLTHQKKK LEGQISARQQ AEEASQESEN ELKEMIETLA RKLNEKSKEQ MELHHQNLNL QETLKRVANC SAPCPQDWIW HGENCYLFSS GSFNWEKSQE KCLSLDAKLL KINSTADLDF IQQAISYSSF PFWMGLSRRN PSYPWLWEDG SPLMPHLFRV RGAVSQTYPS GTCAYIQRGA VYAENCILAA FSICQKKANL RAQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards