UDP-galactose translocator (SLC35A2)

About UDP-galactose translocator

UDP-galactose translocator (SLC35A2) is a protein from Homo sapiens identified by UniProt accession P78381, 396 residues long. MolForge cross-references it against 0 known binders and 256 disease associations.

Target properties

Protein name	UDP-galactose translocator
UniProt accession	P78381
Gene	SLC35A2
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (256)

Diseases linked to this target (Open Targets).

SLC35A2-congenital disorder of glycosylation · score 0.83
congenital disorder of glycosylation · score 0.53
Intellectual disability · score 0.46
genetic disorder · score 0.41
epilepsy · score 0.37
congenital disorder of glycosylation type II · score 0.37
X-linked complex neurodevelopmental disorder · score 0.37
Epileptic encephalopathy · score 0.26
West syndrome · score 0.12
developmental and epileptic encephalopathy, 1 · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78381-F1	alphafold	PREDICTED	79.60	—

Amino-acid sequence (396 residues)

MAAVGAGGST AAPGPGAVSA GALEPGTASA AHRRLKYISL AVLVVQNASL ILSIRYARTL PGDRFFATTA VVMAEVLKGL TCLLLLFAQK RGNVKHLVLF LHEAVLVQYV DTLKLAVPSL IYTLQNNLQY VAISNLPAAT FQVTYQLKIL TTALFSVLML NRSLSRLQWA SLLLLFTGVA IVQAQQAGGG GPRPLDQNPG AGLAAVVASC LSSGFAGVYF EKILKGSSGS VWLRNLQLGL FGTALGLVGL WWAEGTAVAT RGFFFGYTPA VWGVVLNQAF GGLLVAVVVK YADNILKGFA TSLSIVLSTV ASIRLFGFHV DPLFALGAGL VIGAVYLYSL PRGAAKAIAS ASASASGPCV HQQPPGQPPP PQLSSHRGDL ITEPFLPKLL TKVKGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards