CMP-sialic acid transporter (SLC35A1)

About CMP-sialic acid transporter

CMP-sialic acid transporter (SLC35A1) is a protein from Homo sapiens identified by UniProt accession P78382, 337 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	CMP-sialic acid transporter
UniProt accession	P78382
Gene	SLC35A1
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

SLC35A1-congenital disorder of glycosylation · score 0.75
SRD5A3-congenital disorder of glycosylation · score 0.46
congenital disorder of glycosylation type II · score 0.37
Macrothrombocytopenia · score 0.19
genetic disorder · score 0.19
Seizure · score 0.18
congenital disorder of glycosylation · score 0.18
appendicular lean mass · score 0.12
monocyte percentage of leukocytes · score 0.09
self reported educational attainment · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78382-F1	alphafold	PREDICTED	88.02	—

Amino-acid sequence (337 residues)

MAAPRDNVTL LFKLYCLAVM TLMAAVYTIA LRYTRTSDKE LYFSTTAVCI TEVIKLLLSV GILAKETGSL GRFKASLREN VLGSPKELLK LSVPSLVYAV QNNMAFLALS NLDAAVYQVT YQLKIPCTAL CTVLMLNRTL SKLQWVSVFM LCAGVTLVQW KPAQATKVVV EQNPLLGFGA IAIAVLCSGF AGVYFEKVLK SSDTSLWVRN IQMYLSGIIV TLAGVYLSDG AEIKEKGFFY GYTYYVWFVI FLASVGGLYT SVVVKYTDNI MKGFSAAAAI VLSTIASVML FGLQITLTFA LGTLLVCVSI YLYGLPRQDT TSIQQGETAS KERVIGV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards