About Keratin, type II cuticular Hb3
Keratin, type II cuticular Hb3 (KRT83) is a protein
from Homo sapiens identified by UniProt accession
P78385, 493 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Keratin, type II cuticular Hb3 |
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| UniProt accession | P78385 |
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| Gene | KRT83 |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- monilethrix · score 0.69
- erythrokeratodermia variabilis · score 0.44
- head and neck squamous cell carcinoma · score 0.18
- prostate adenocarcinoma · score 0.18
- actinic keratosis · score 0.11
- plasma fibronectin deficiency · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.06
- Hereditary persistence of alpha-fetoprotein · score 0.04
- congenital enteropathy due to enteropeptidase deficiency · score 0.04
- gastric mucosal hypertrophy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78385-F1 | alphafold | PREDICTED | 72.81 | — |
Amino-acid sequence (493 residues)
MTCGFNSIGC GFRPGNFSCV SACGPRPSRC CITAAPYRGI SCYRGLTGGF GSHSVCGGFR AGSCGRSFGY RSGGVCGPSP PCITTVSVNE SLLTPLNLEI DPNAQCVKQE EKEQIKSLNS RFAAFIDKVR FLEQQNKLLE TKLQFYQNRE CCQSNLEPLF AGYIETLRRE AECVEADSGR LASELNHVQE VLEGYKKKYE EEVALRATAE NEFVALKKDV DCAYLRKSDL EANVEALIQE IDFLRRLYEE EIRILQSHIS DTSVVVKLDN SRDLNMDCIV AEIKAQYDDI ATRSRAEAES WYRSKCEEMK ATVIRHGETL RRTKEEINEL NRMIQRLTAE VENAKCQNSK LEAAVAQSEQ QGEAALSDAR CKLAELEGAL QKAKQDMACL IREYQEVMNS KLGLDIEIAT YRRLLEGEEQ RLCEGVEAVN VCVSSSRGGV VCGDLCVSGS RPVTGSVCSA PCNGNLVVST GLCKPCGQLN TTCGGGSCGQ GRH
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