Keratin, type II cuticular Hb5 (KRT85)

About Keratin, type II cuticular Hb5

Keratin, type II cuticular Hb5 (KRT85) is a protein from Homo sapiens identified by UniProt accession P78386, 507 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Keratin, type II cuticular Hb5
UniProt accession	P78386
Gene	KRT85
Organism	Homo sapiens
Length	507 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

pure hair and nail ectodermal dysplasia · score 0.59
ovarian cancer · score 0.18
head and neck squamous cell carcinoma · score 0.18
prostate adenocarcinoma · score 0.18
clear cell renal carcinoma · score 0.18
breast adenocarcinoma · score 0.18
thyroid gland adenocarcinoma · score 0.16
actinic keratosis · score 0.03
psoriasis · score 0.01
cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78386-F1	alphafold	PREDICTED	72.12	—

Amino-acid sequence (507 residues)

MSCRSYRISS GCGVTRNFSS CSAVAPKTGN RCCISAAPYR GVSCYRGLTG FGSRSLCNLG SCGPRIAVGG FRAGSCGRSF GYRSGGVCGP SPPCITTVSV NESLLTPLNL EIDPNAQCVK QEEKEQIKSL NSRFAAFIDK VRFLEQQNKL LETKWQFYQN QRCCESNLEP LFSGYIETLR REAECVEADS GRLASELNHV QEVLEGYKKK YEEEVALRAT AENEFVVLKK DVDCAYLRKS DLEANVEALV EESSFLRRLY EEEIRVLQAH ISDTSVIVKM DNSRDLNMDC IIAEIKAQYD DVASRSRAEA ESWYRSKCEE MKATVIRHGE TLRRTKEEIN ELNRMIQRLT AEIENAKCQR AKLEAAVAEA EQQGEAALSD ARCKLAELEG ALQKAKQDMA CLLKEYQEVM NSKLGLDIEI ATYRRLLEGE EHRLCEGVGS VNVCVSSSRG GVSCGGLSYS TTPGRQITSG PSAIGGSITV VAPDSCAPCQ PRSSSFSCGS SRSVRFA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards