About Melanoma antigen preferentially expressed in tumors
Melanoma antigen preferentially expressed in tumors (PRAME) is a protein
from Homo sapiens identified by UniProt accession
P78395, 509 residues long.
MolForge cross-references it against 0 known binders and
302 disease associations.
Target properties
| Protein name | Melanoma antigen preferentially expressed in tumors |
|---|
| UniProt accession | P78395 |
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| Gene | PRAME |
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| Organism | Homo sapiens |
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| Length | 509 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (302)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- Myopia · score 0.16
- age at onset · score 0.16
- neoplasm · score 0.10
- melanoma · score 0.10
- acute myeloid leukemia · score 0.10
- azoospermia · score 0.09
- hepatocellular carcinoma · score 0.08
- testosterone measurement · score 0.08
- partial chromosome Y deletion · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78395-F1 | alphafold | PREDICTED | 81.48 | — |
Amino-acid sequence (509 residues)
MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR ELFPPLFMAA FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD LFLKEGACDE LFSYLIEKVK RKKNVLRLCC KKLKIFAMPM QDIKMILKMV QLDSIEDLEV TCTWKLPTLA KFSPYLGQMI NLRRLLLSHI HASSYISPEK EEQYIAQFTS QFLSLQCLQA LYVDSLFFLR GRLDQLLRHV MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ LSVLSLSGVM LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP SLSHCSQLTT LSFYGNSISI SALQSLLQHL IGLSNLTHVL YPVPLESYED IHGTLHLERL AYLHARLREL LCELGRPSMV WLSANPCPHC GDRTFYDPEP ILCPCFMPN
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