Butyrophilin subfamily 3 member A2 (BTN3A2)

About Butyrophilin subfamily 3 member A2

Butyrophilin subfamily 3 member A2 (BTN3A2) is a protein from Homo sapiens identified by UniProt accession P78410, 334 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Butyrophilin subfamily 3 member A2
UniProt accession	P78410
Gene	BTN3A2
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.32
diet measurement · score 0.27
mathematical ability · score 0.26
cognitive function measurement · score 0.24
major depressive disorder · score 0.22
Calcium channel blocker use measurement · score 0.22
depressive symptom measurement · score 0.21
bipolar disorder · score 0.21
mean corpuscular volume · score 0.20
self reported educational attainment · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78410-F1	alphafold	PREDICTED	89.96	—

Amino-acid sequence (334 residues)

MKMASSLAFL LLNFHVSLLL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSNL HVEVKGYEDG GIHLECRSTG WYPQPQIQWS NAKGENIPAV EAPVVADGVG LYEVAASVIM RGGSGEGVSC IIRNSLLGLE KTASISIADP FFRSAQPWIA ALAGTLPILL LLLAGASYFL WRQQKEITAL SSEIESEQEM KEMGYAATER EISLRESLQE ELKRKKIQYL TRGEESSSDT NKSA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards