Iroquois-class homeodomain protein IRX-5 (IRX5)

About Iroquois-class homeodomain protein IRX-5

Iroquois-class homeodomain protein IRX-5 (IRX5) is a protein from Homo sapiens identified by UniProt accession P78411, 483 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.

Target properties

Protein name	Iroquois-class homeodomain protein IRX-5
UniProt accession	P78411
Gene	IRX5
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (51)

Diseases linked to this target (Open Targets).

Craniofacial dysplasia-osteopenia syndrome · score 0.70
craniofacial dysplasia - osteopenia syndrome · score 0.68
neurodegenerative disease · score 0.51
heel bone mineral density · score 0.41
bone quantitative ultrasound measurement · score 0.35
body height · score 0.32
balding measurement · score 0.26
hypospadias · score 0.26
alkaline phosphatase measurement · score 0.25
bone density · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78411-F1	alphafold	PREDICTED	54.31	—

Amino-acid sequence (483 residues)

MSYPQGYLYQ PSASLALYSC PAYSTSVISG PRTDELGRSS SGSAFSPYAG STAFTAPSPG YNSHLQYGAD PAAAAAAAFS SYVGSPYDHT PGMAGSLGYH PYAAPLGSYP YGDPAYRKNA TRDATATLKA WLNEHRKNPY PTKGEKIMLA IITKMTLTQV STWFANARRR LKKENKMTWT PRNRSEDEEE EENIDLEKND EDEPQKPEDK GDPEGPEAGG AEQKAASGCE RLQGPPTPAG KETEGSLSDS DFKEPPSEGR LDALQGPPRT GGPSPAGPAA ARLAEDPAPH YPAGAPAPGP HPAAGEVPPG PGGPSVIHSP PPPPPPAVLA KPKLWSLAEI ATSSDKVKDG GGGNEGSPCP PCPGPIAGQA LGGSRASPAP APSRSPSAQC PFPGGTVLSR PLYYTAPFYP GYTNYGSFGH LHGHPGPGPG PTTGPGSHFN GLNQTVLNRA DALAKDPKML RSQSQLDLCK DSPYELKKGM SDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards