Iroquois-class homeodomain protein IRX-4 (IRX4)

About Iroquois-class homeodomain protein IRX-4

Iroquois-class homeodomain protein IRX-4 (IRX4) is a protein from Homo sapiens identified by UniProt accession P78413, 519 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.

Target properties

Protein name	Iroquois-class homeodomain protein IRX-4
UniProt accession	P78413
Gene	IRX4
Organism	Homo sapiens
Length	519 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (170)

Diseases linked to this target (Open Targets).

prostate carcinoma · score 0.44
electrocardiography · score 0.44
ventricular septal defect 1 · score 0.42
protein measurement · score 0.25
meningococcal infection · score 0.25
male reproductive organ cancer · score 0.25
prostate cancer · score 0.25
PHF-tau measurement · score 0.23
drug use measurement · score 0.17
optic cup area measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78413-F1	alphafold	PREDICTED	53.03	—

Amino-acid sequence (519 residues)

MSYPQFGYPY SSAPQFLMAT NSLSTCCESG GRTLADSGPA ASAQAPVYCP VYESRLLATA RHELNSAAAL GVYGGPYGGS QGYGNYVTYG SEASAFYSLN SFDSKDGSGS AHGGLAPAAA AYYPYEPALG QYPYDRYGTM DSGTRRKNAT RETTSTLKAW LQEHRKNPYP TKGEKIMLAI ITKMTLTQVS TWFANARRRL KKENKMTWPP RNKCADEKRP YAEGEEEEGG EEEAREEPLK SSKNAEPVGK EEKELELSDL DDFDPLEAEP PACELKPPFH SLDGGLERVP AAPDGPVKEA SGALRMSLAA GGGAALDEDL ERARSCLRSA AAGPEPLPGA EGGPQVCEAK LGFVPAGASA GLEAKPRIWS LAHTATAAAA AATSLSQTEF PSCMLKRQGP AAPAAVSSAP ATSPSVALPH SGALDRHQDS PVTSLRNWVD GVFHDPILRH STLNQAWATA KGALLDPGPL GRSLGAGANV LTAPLARAFP PAVPQDAPAA GAARELLALP KAGGKPFCA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards