Iroquois-class homeodomain protein IRX-1 (IRX1)

About Iroquois-class homeodomain protein IRX-1

Iroquois-class homeodomain protein IRX-1 (IRX1) is a protein from Homo sapiens identified by UniProt accession P78414, 480 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.

Target properties

Protein name	Iroquois-class homeodomain protein IRX-1
UniProt accession	P78414
Gene	IRX1
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (149)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
body mass index · score 0.39
Red cell distribution width · score 0.39
waist-hip ratio · score 0.38
body weight · score 0.38
systolic blood pressure · score 0.36
diastolic blood pressure · score 0.36
vital capacity · score 0.35
mathematical ability · score 0.34
self reported educational attainment · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P78414-F1	alphafold	PREDICTED	54.71	—

Amino-acid sequence (480 residues)

MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG GAGAAAVTSV LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD NPGVHPATFA AHTAPAYYPY GQFQYGDPGR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK VTWGARSKDQ EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ SNEDDEDKAE APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA PLQHPAFLPS HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA PHGPHLPAPP PPQPPVAIAP GALNGDKASV RSSPTLPERD LVPRPDSPAQ QLKSPFQPVR DNSLAPQEGT PRILAALPSA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards