About Iroquois-class homeodomain protein IRX-3
Iroquois-class homeodomain protein IRX-3 (IRX3) is a protein
from Homo sapiens identified by UniProt accession
P78415, 501 residues long.
MolForge cross-references it against 0 known binders and
177 disease associations.
Target properties
| Protein name | Iroquois-class homeodomain protein IRX-3 |
|---|
| UniProt accession | P78415 |
|---|
| Gene | IRX3 |
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| Organism | Homo sapiens |
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| Length | 501 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (177)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.41
- calcium measurement · score 0.35
- prostate carcinoma · score 0.31
- self reported educational attainment · score 0.30
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.27
- type 2 diabetes mellitus · score 0.27
- neutrophil count · score 0.27
- lean body mass · score 0.26
- lymphocyte percentage of leukocytes · score 0.26
- response to corticosteroid · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P78415-F1 | alphafold | PREDICTED | 53.98 | — |
Amino-acid sequence (501 residues)
MSFPQLGYQY IRPLYPSERP GAAGGSGGSA GARGGLGAGA SELNASGSLS NVLSSVYGAP YAAAAAAAAA QGYGAFLPYA AELPIFPQLG AQYELKDSPG VQHPAAAAAF PHPHPAFYPY GQYQFGDPSR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK MTWAPRSRTD EEGNAYGSER EEEDEEEDEE DGKRELELEE EELGGEEEDT GGEGLADDDE DEEIDLENLD GAATEPELSL AGAARRDGDL GLGPISDSKN SDSEDSSEGL EDRPLPVLSL APAPPPVAVA SPSLPSPPVS LDPCAPAPAP ASALQKPKIW SLAETATSPD NPRRSPPGAG GSPPGAAVAP SALQLSPAAA AAAAHRLVSA PLGKFPAWTN RPFPGPPPGP RLHPLSLLGS APPHLLGLPG AAGHPAAAAA FARPAEPEGG TDRCSALEVE KKLLKTAFQP VPRRPQNHLD AALVLSALSS S
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